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Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma.
Tan S, Zhao J, Sun Z, Cao S, Niu K, Zhong Y, Wang H, Shi L, Pan H, Hu J, Qian L, Liu N, Yuan J. Tan S, et al. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14231-14242. doi: 10.1073/pnas.2005353117. Epub 2020 Jun 8. Proc Natl Acad Sci U S A. 2020. PMID: 32513687 Free PMC article.
Hepatocyte-specific deletion of TAK1 in Tak1(deltaHEP) mice promotes liver fibrosis and hepatocellular carcinoma (HCC) formation. Here, we report that genetic inactivation of RIPK1 kinase using a kinase dead knockin D138N mutation in Tak1(deltaHEP) mice inhibits the expres …
Hepatocyte-specific deletion of TAK1 in Tak1(deltaHEP) mice promotes liver fibrosis and hepatocellular carcinoma (HCC) formation. Her …
TAK1 regulates hepatic cell survival and carcinogenesis.
Roh YS, Song J, Seki E. Roh YS, et al. J Gastroenterol. 2014 Feb;49(2):185-94. doi: 10.1007/s00535-013-0931-x. Epub 2014 Jan 21. J Gastroenterol. 2014. PMID: 24443058 Free PMC article. Review.
TGF-beta-activated kinase 1 (TAK1 or MAP3K7) is an intracellular hub molecule that regulates both nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling pathways that play key roles in development, cell survival, immune response, metabolism …
TGF-beta-activated kinase 1 (TAK1 or MAP3K7) is an intracellular hub molecule that regulates both nuclear factor-kappaB (NF-kappaB) a …
High Expression of LINC01268 is Positively Associated with Hepatocellular Carcinoma Progression via Regulating MAP3K7.
Jin X, Fu W, Li D, Wang N, Chen J, Zeng Z, Guo J, Liu H, Zhong X, Peng H, Yu X, Sun J, Zhang X, Wang X, Xu B, Lin Y, Liu J, Kutter C, Li Y. Jin X, et al. Onco Targets Ther. 2021 Mar 8;14:1753-1769. doi: 10.2147/OTT.S295814. eCollection 2021. Onco Targets Ther. 2021. PMID: 33727826 Free PMC article.
RT-qPCR and Western blot were applied to inspect the effects of depletion and overexpression of LINC01268 on MAP3K7 expression. HCC cell proliferation and apoptosis were also investigated by simultaneous overexpression of LINC01268 and knockdown of MAP3K7, in order …
RT-qPCR and Western blot were applied to inspect the effects of depletion and overexpression of LINC01268 on MAP3K7 expression. HCC c …
iRhom2 Promotes Hepatic Steatosis by Activating MAP3K7-Dependent Pathway.
Xu M, Ge C, Zhu L, Qin Y, Du C, Lou D, Li Q, Hu L, Sun Y, Dai X, Xiong M, Long T, Zhan J, Kuang Q, Li H, Yang Q, Huang P, Teng X, Feng J, Wu Y, Dong W, Wang B, Tan J. Xu M, et al. Hepatology. 2021 Apr;73(4):1346-1364. doi: 10.1002/hep.31436. Hepatology. 2021. PMID: 32592194
BACKGROUND AND AIMS: Nonalcoholic fatty liver disease (NAFLD) has been widely recognized as a precursor to metabolic complications. ...The iRhom2/MAP3K7 axis is essential for iRhom2-regulated liver steatosis. CONCLUSIONS: iRhom2 may represent a therapeutic ta …
BACKGROUND AND AIMS: Nonalcoholic fatty liver disease (NAFLD) has been widely recognized as a precursor to metabolic complications. . …
New insight into BIRC3: A novel prognostic indicator and a potential therapeutic target for liver cancer.
Fu PY, Hu B, Ma XL, Yang ZF, Yu MC, Sun HX, Huang A, Zhang X, Wang J, Hu ZQ, Zhou CH, Tang WG, Ning R, Xu Y, Zhou J. Fu PY, et al. J Cell Biochem. 2019 Apr;120(4):6035-6045. doi: 10.1002/jcb.27890. Epub 2018 Oct 28. J Cell Biochem. 2019. PMID: 30368883
BIRC3 promotes HCC epithelial-mesenchymal transition (EMT), cell migration, and metastasis via upregulating MAP3K7, therefore, inducing ERK1/2 phosphorylation. The specific BIRC3 inhibitor AT-406 can inhibit HCC cell proliferation and reduce pulmonary metastases. CONCLUSIO …
BIRC3 promotes HCC epithelial-mesenchymal transition (EMT), cell migration, and metastasis via upregulating MAP3K7, therefore, induci …
RHBDF2 is correlated with immune infiltrates in hepatocellular carcinoma and may have potential as a biomarker.
Gong H, Xie H, Huangfu Z, Zhang S, Tang Y, Xiao M, Li M, Wang Y. Gong H, et al. FEBS Open Bio. 2023 May;13(5):881-897. doi: 10.1002/2211-5463.13598. Epub 2023 Apr 5. FEBS Open Bio. 2023. PMID: 36943228 Free PMC article.
The gene for rhomboid 5 homolog 2 (IRHom2), which encodes the rhombus protease iRhom2, activates the MAP3K7-dependent pathway and promotes hepatic steatosis. Thus, we hypothesized an involvement of this gene in HCC. ...
The gene for rhomboid 5 homolog 2 (IRHom2), which encodes the rhombus protease iRhom2, activates the MAP3K7-dependent pathway and pro …
Tripartite motif-containing protein 31 confers protection against nonalcoholic steatohepatitis by deactivating mitogen-activated protein kinase kinase kinase 7.
Xu MX, Tan J, Ge CX, Dong W, Zhang LT, Zhu LC, Zhao JJ, Wang LY, Liu J, Wei H, Sun Y, Dai XL, Kuang Q, Li YL, Li H, Liu JY, Zou L, Liang RR, Zhang CF, Xu J, Wang BC. Xu MX, et al. Hepatology. 2023 Jan 1;77(1):124-143. doi: 10.1002/hep.32526. Epub 2022 Jul 7. Hepatology. 2023. PMID: 35429173
APPROACH RESULTS: We identified the RING-type E3 ubiquitin transferase-tripartite motif-containing protein 31 (TRIM31), a member of the E3 ubiquitin ligases family, as an efficient endogenous inhibitor of transforming growth factor-beta-activated kinase 1 (mitogen-activated prote …
APPROACH RESULTS: We identified the RING-type E3 ubiquitin transferase-tripartite motif-containing protein 31 (TRIM31), a member of the E3 u …
Genetic insights into Map3k-dependent proliferative expansion of T cells.
Suddason T, Gallagher E. Suddason T, et al. Cell Cycle. 2016 Aug 2;15(15):1956-60. doi: 10.1080/15384101.2016.1189042. Epub 2016 May 31. Cell Cycle. 2016. PMID: 27246297 Free PMC article.
Mekk1 is one of the 19 Ste11-like Map3ks, and Mekk1 signaling regulates iNKT cell proliferative expansion in response to glycolipid antigens and T cell homeostasis in the liver. Tak1 (encoded by Map3k7), a related Map3k to Mekk1, similarly regulates the proliferativ …
Mekk1 is one of the 19 Ste11-like Map3ks, and Mekk1 signaling regulates iNKT cell proliferative expansion in response to glycolipid antigens …
TAK1 binding protein 2 is essential for liver protection from stressors.
Ikeda Y, Morioka S, Matsumoto K, Ninomiya-Tsuji J. Ikeda Y, et al. PLoS One. 2014 Feb 3;9(2):e88037. doi: 10.1371/journal.pone.0088037. eCollection 2014. PLoS One. 2014. PMID: 24498425 Free PMC article.
Protection against hepatic cell damage and cell death is important for liver function and homeostasis. TAK1 (MAP3K7) is an intermediate of stressors such as bacterial moieties-induced signal transduction pathways in several cell types. ...Mice having hepatocyte-spec …
Protection against hepatic cell damage and cell death is important for liver function and homeostasis. TAK1 (MAP3K7) is an int …
Development of a Toll-Like Receptor-Based Gene Signature That Can Predict Prognosis, Tumor Microenvironment, and Chemotherapy Response for Hepatocellular Carcinoma.
Liu L, Liu B, Yu J, Zhang D, Shi J, Liang P. Liu L, et al. Front Mol Biosci. 2021 Sep 21;8:729789. doi: 10.3389/fmolb.2021.729789. eCollection 2021. Front Mol Biosci. 2021. PMID: 34621787 Free PMC article.
The expression of TLRs in this signature was verified in HCC and normal liver tissues by Western blot. Following si-MAP2K2 transfection, colony formation and apoptosis of Huh7 and HepG2 cells were examined. Results: Herein, we identified 60 HCC-specific TLRs. A TLR-based g …
The expression of TLRs in this signature was verified in HCC and normal liver tissues by Western blot. Following si-MAP2K2 transfecti …
21 results